Publicaciones

Induction of High Levels of Specific Humoral and Cellular Responses to SARS-CoV-2 After the Administration of Covid-19 mRNA Vaccines Requires Several Days.

Sergio Gil-Manso, Diego Carbonell, Luis López-Fernández, Iria Miguens, Roberto Alonso, Ismael Buño, Patricia Muñoz, Jordi Ochando, Marjorie Pion and Rafael Correa-Rocha.

October 2021. ORIGINAL RESEARCH ARTICLE. https://doi.org/10.3389/fimmu.2021.726960

This refractory period in the induction of specific immunity observed after completing the vaccination could constitute a window of higher infection risk, which could explain some emerging cases of SARS-CoV-2 infection in vaccinated people.

Differential effects of the second SARS-CoV-2 mRNA vaccine dose on T cell immunity.

Daniel Lozano-Ojalvo, Carmen Camara  Eduardo Lopez-Granados, Pilar Nozal, Lucía Del Pino-Molina, Luz Yadira Bravo-Gallego, Estela Paz-Artal , Marjorie Pion , Rafael Correa-Rocha , Alberto Ortiz, Marcos Lopez-Hoyos, Marta Erro Iribarren, Jose Portoles, Maria Pilar Rojo-Portoles, Gloria Ojeda, Isabel Cervera, Maria Gonzalez-Perez, Irene Bodega-Mayor, Maria Montes-Casado, Pilar Portoles, Mayte Perez-Olmeda, Jesus Oteo, Rodrigo Sanchez-Tarjuelo, Venu Pothula, Megan Schwarz, Manisha Brahmachary, Anthony Tanoto Tan, Nina Le Bert, Cecilia Berin, Antonio Bertoletti, Ernesto Guccione, Jordi Ochando.

Cell Reports 36, 109570 August 24, 2021 DOI: 10.1016/j.celrep.2021.109570

The rapid development of mRNA-based vaccines against the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) led to the design of accelerated vaccination schedules that have been extremely effective in naive individuals.

The Presence of a Marked Imbalance Between Regulatory T Cells and Effector T Cells Reveals That Tolerance Mechanisms Could Be Compromised in Heart Transplant Children.

Esther Bernaldo-de-Quirós, Jacobo López-Abente, Manuela Camino Nuria Gil, Esther Panadero, Rocío López-Esteban, Marta Martínez-Bonet, Marjorie Pion, Rafael Correa-Rocha.

Transplant Direct. 2021 2021 Apr 23;7(5):e693 DOI: 10.1097/TXD.0000000000001152

These results reveal that interventions employed in pediatric heart transplantation (immunosuppression and thymectomy) could induce, as an inevitable consequence, a dysregulation in the immunologic status characterized by a marked imbalance between Treg and T effector, which could jeopardize the preservation of tolerance during the period with the higher incidence of acute rejection.

Ectopic FOXP3 Expression in Combination with TGF-β1 and IL-2 Stimulation Generates Limited Suppressive Function in Human Primary Activated Thymocytes Ex Vivo.

Jorge Gallego-Valle, Sergio Gil-Manso, Ana Pita, Esther Bernaldo-de-Quirós, Rocío López-Esteban, Marta Martínez-Bonet, Verónica Astrid Pérez-Fernández, Ramón Pérez-Caballero, Carlos Pardo, Juan-Miguel Gil-Jaurena, Rafael Correa-Rocha and Marjorie Pion.

Biomedicines 2021, 9(5), 461 DOI: 10.3390/biomedicines9050461

Regulatory T cells (Tregs), which are characterized by the expression of the transcription factor forkhead box P3 (FOXP3), are the main immune cells that induce tolerance and are regulators of immune homeostasis.

Colchicine treatment in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome: A multicenter study in Spain.

Cristian Quintana-Ortega, Elena Seoane-Reula, Laura Fernández, Marisol Camacho, Peter Olbrich, Olaf Neth, Sara Murias, Clara Udaondo, Agustín Remesal, Cristina Calvo, Rosa Alcobendas.

Eur J Rheumatol 2021; 8(2): 73-8 DOI: 10.5152/eurjrheum.2020.20102

Objective: To evaluate the efficacy of colchicine therapy in pediatric patients with PFAPA syndrome who present with an incomplete response to the standard treatment or with frequent episodes (an interval of less than 14 days between two disease flares).

Clinical course of severe patients with COVID-19 treated with tocilizumab: report from a cohort study in Spain.

Esther Chamorro-de-Vega, Carmen-Guadalupe Rodriguez-Gonzalez, Silvia Manrique-Rodríguez, et. al.

Expert Review of Clinical Pharmacology - Volume 14, 2021 DOI:10.1080/17512433.2021.1875819

Background: We report the long-term outcomes, changes in laboratory parameters, the incidence of secondary nosocomial infections and treatment cost of a Spanish cohort of patients with severe COVID-19 that received tocilizumab (TCZ).

Coronavirus disease 2019 in patients with inborn errors of immunity: An international study.

sabelle Meyts, Giorgia Bucciol, Isabella Quinti et.al.

J Allergy Clin Immunol 2021 Feb;147(2):520-531. DOI: 10.1016/j.jaci.2020.09.010

Background: There is uncertainty about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in individuals with rare inborn errors of immunity (IEI), a population at risk of developing severe coronavirus disease 2019. This is relevant not only for these patients but also for the general population, because studies of IEIs can unveil key requirements for host defense.

Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation.

Clemente, Simon Urschel, Lori West, Marjorie Pion and Rafael Correa-Rocha.

Sci Rep 2021 Jan 12;11(1):827. DOI: 10.1038/s41598-020-80567-9

CD25, the alpha chain of the IL-2 receptor, is expressed on activated effector T cells that mediate immune graft damage.

Pigmented Dermatofibrosarcoma Protuberans: Description of a pediatric case.

Berenguer-Fröhner, Verónica Parra-Blanco, Minia Campos-Domínguez.

Rev Chil Pediatr 2020 Feb;91(1):99-104. Epub 2019 Dec 3. DOI: 10.32641/rchped.v91i1.1303. 

Introduction: Bednar tumor is a rare low-grade sarcoma considered the pigmented variant of dermatofibrosarco ma protuberans (DFSP).

Imbalance in T-Helper 17 Cells and Targeted Therapy in an Infant with SAM-like Syndrome.

Ángela Hernández-Martín, Rebeca Kennedy-Batalla, Elvira Cañedo, Esther Bernaldo-de-Quirós, Begoña Carazo-Gallego, Angel Vera, Antonio Torrelo, Lucero Noguera-Morel, Rogelio González-Sarmiento, Marieke Bolling, Marta Martínez-Bonet, Marjorie Pion, Rafael Correa-Rocha.

N Engl J Med  2019 Nov 28;381(22):2176-2178. DOI: 10.1056/NEJMc1908531

The SAM syndrome, which is characterized by severe dermatitis, multiple allergies, and metabolic wasting (Online Mendelian Inheritance in Man number, 615508), is a congenital skin disease caused by mutations in the genes encoding either desmoglein-1 (DSG1) or desmoplakin (DSP).